Research Interest

Develop novel constraint optimization algorithms and AI algorithms based on digital cell mechanism models and industrial biotechnology big data to enhance strain productivity, substrate utilization efficiency, and high-throughput construction efficiency.

Education & Professional Experience

1、Education Background

2008.09-2012.06, Beijing University of Chemical Technology, Chemical Engineering, Bachelor’s Degree.

2012.01-2013.09, University College Dublin, Chemical and Bioprocess Engineering, Master’s Degree

20115.010-2016.10, University College Dublin, Chemical Engineering, Visiting Scholar

2014.09-2019.12, Beijing University of Chemical Technology, Life Science and Technology, Ph.D.

2、Work Experience

2020.04-2025.09, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences. Research Assistant

2025.09 to Present, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences.，Biodesign Centre，Associate Researcher

Honors and Awards

Selected for the Fourth Edition of the Chinese Academy of Sciences’ “Master Craftsmen (Teams) in Science” in 2023: Engineering Microorganism Casting Scientific Facilities Team

Selected Publications

Published over 20 articles in domestic and international journals. Applied for 3 invention patents. Representative papers from the past 5 years:

  1. Cai, J.#; Liu, J.; Wei, F.; Wu, W.; Xu, W.; Wang, Y.; Yuan, Q.; Ma, H*. Exploring Biomass Precursor Synthesis as a Determinant in Microbial Adaptation to Unadapted Carbon Sources. Research 2025, https://doi.org/10.34133/research.0881.
  2. Xu, W.#; Cai, J.#; Wu, W.; Yuan, Q.; Mao, Z.; Ma, H. Improving Metabolic Engineering Design with Enzyme-Thermo Optimization. Metab Eng 2025, 91, 356–365.
  3. Wei, F.#; Cai, J.#; Mao, Y.; Wang, R.; Li, H.; Mao, Z.; Liao, X.; Li, A.; Deng, X.; Li, F.; Yuan, Q.; Ma, H. Unveiling Metabolic Engineering Strategies by Quantitative Heterologous Pathway Design. Advanced Science 2024, 11 (45)
  4. Cai, J.#; Liao, X.; Mao, Y.; Wang, R.; Li, H.; Ma, H. Designing Gene Manipulation Schedules for High Throughput Parallel Construction of Objective Strains. Biotechnol J 2023, 18 (9)
  5. Cai, J.#; Tan, T.; Chan, S. H. J. Predicting Nash Equilibria for Microbial Metabolic Interactions. Bioinformatics 2020, 36 (24)